Sinner had been attributable to play singles and doubles at Roland Garros.
His withdrawal implies that Novak Djokovic would be the prime seed within the singles when the draw is made on Thursday.
A lot of gamers will miss the Paris Video games, both by sickness or harm.
Marketa Vondrousova, silver medallist in Tokyo three years in the past, pulled out on Tuesday with a hand harm, whereas Polish world quantity seven Hubert Hurkacz additionally withdrew.
Different notable absentees embrace Britain’s Emma Raducanu, world quantity three Aryna Sabalenka and two-time Wimbledon runner-up Ons Jabeur.
However Djokovic, Wimbledon champion Carlos Alcaraz and US Open winner Coco Gauff are all slated to play.
The Olympics happen simply 13 days after Wimbledon ended and end three weeks earlier than the US Open begins.