Holders and 21-times winners Wigan Warriors will face Hull FC at residence within the fourth spherical of the Problem Cup.
The brand new-look Black and Whites, now coached by John Cartwright, started their Tremendous League season with a shock win away to Catalans Dragons however face the hardest proposition to progress within the cup.
Large-killers Bradford Bulls, the Championship facet who noticed off Tremendous League facet Castleford Tigers within the final spherical, have been rewarded with a visit to play troubled Salford.
Batley Bulldogs will likely be away to 2023 winners Leigh Leopards, whereas Featherstone Rovers make the journey to Perpignan to tackle Catalans Dragons, who triumphed in opposition to Warrington within the 2018 last.
Oldham will even be on the highway, away to Hull KR, with the ties to be performed over the weekend of 15-16 March.
Full draw
Widnes Vikings v Warrington Wolves
Salford Crimson Devils v Bradford Bulls
St Helens v Leeds Rhinos
Hull KR v Oldham
Leigh Leopards v Batley Bulldogs
Catalans Dragons v Featherstone Rovers
Huddersfield Giants v Wakefield Trinity
Wigan Warriors v Hull FC